Dataset Information
A quantitative model of the initiation of DNA replication in Saccharomyces cerevisiae predicts the effects of system perturbations
Ontology highlight
ABSTRACT: Requires input from Chen2004(BIOMD0000000056) model but did not work correctly even after integrating both models.
SUBMITTER: Ashley Xavier
PROVIDER: MODEL1812050001 | biostudies-other |
SECONDARY ACCESSION(S): 22738223
REPOSITORIES: biostudies-other
Publications
A quantitative model of the initiation of DNA replication in Saccharomyces cerevisiae predicts the effects of system perturbations.
BMC systems biology 20120627
<h4>Background</h4>Eukaryotic cell proliferation involves DNA replication, a tightly regulated process mediated by a multitude of protein factors. In budding yeast, the initiation of replication is facilitated by the heterohexameric origin recognition complex (ORC). ORC binds to specific origins of replication and then serves as a scaffold for the recruitment of other factors such as Cdt1, Cdc6, the Mcm2-7 complex, Cdc45 and the Dbf4-Cdc7 kinase complex. While many of the mechanisms controlling ...[more]
