Henze2017 - A Dynamical Model for Activating and Silencing the Mitotic Checkpoint

ABSTRACT:

The spindle assembly checkpoint (SAC) is an evolutionarily conserved mechanism, exclusively sensitive to the states of kinetochores attached to microtubules. During metaphase, the anaphase-promoting complex/cyclosome (APC/C) is inhibited by the SAC but it rapidly switches to its active form following proper attachment of the final spindle. It had been thought that APC/C activity is an all-or-nothing response, but recent findings have demonstrated that it switches steadily. In this study, we develop a detailed mathematical model that considers all 92 human kinetochores and all major proteins involved in SAC activation and silencing. We perform deterministic and spatially-stochast

SUBMITTER: Tung Nguyen 

PROVIDER: MODEL1812210002 | biostudies-other |

SECONDARY ACCESSION(S): 28634351

REPOSITORIES: biostudies-other