Dataset Information
Robertson-Tessi M 2012 A model of tumor Immune interaction
Ontology highlight
ABSTRACT: Its a mathematical model presenting the interaction between a growing tumor and immune system. Model involves tumor cells, dendritic cell, helper Tcells, regulatory Tcells, effector cells and certain cytokines (e.g. TGFbeta, IL10, IL2 ) produced by these cells. It represent a dynamic regulation of tumor production/killing by different immune cells and cytokines.
ORGANISM(S): Homo sapiens
SUBMITTER: Lucian Smith
PROVIDER: MODEL1901250001 | biostudies-other |
SECONDARY ACCESSION(S): 22051568
REPOSITORIES: biostudies-other
Publications
A mathematical model of tumor-immune interactions.
Journal of theoretical biology 20111028
A mathematical model of the interactions between a growing tumor and the immune system is presented. The equations and parameters of the model are based on experimental and clinical results from published studies. The model includes the primary cell populations involved in effector T-cell mediated tumor killing: regulatory T cells, helper T cells, and dendritic cells. A key feature is the inclusion of multiple mechanisms of immunosuppression through the main cytokines and growth factors mediatin ...[more]