Dataset Information
Shaw 2019 - Yeast GPCR Ternary Complex Model
Ontology highlight
ABSTRACT: SBML model exported from PottersWheel on 2019-01-17 12:49:15. This model was created via Matlab and automatically converted to SBML.
SUBMITTER: Graham Ladds
PROVIDER: MODEL1901300001 | biostudies-other |
SECONDARY ACCESSION(S): 30955892
REPOSITORIES: biostudies-other
Publications
Engineering a Model Cell for Rational Tuning of GPCR Signaling.
Cell 20190404 3
G protein-coupled receptor (GPCR) signaling is the primary method eukaryotes use to respond to specific cues in their environment. However, the relationship between stimulus and response for each GPCR is difficult to predict due to diversity in natural signal transduction architecture and expression. Using genome engineering in yeast, we constructed an insulated, modular GPCR signal transduction system to study how the response to stimuli can be predictably tuned using synthetic tools. We deline ...[more]
