Dataset Information
Shaw2019 - Digital biosensor model from Yeast
Ontology highlight
ABSTRACT: SBML model exported from PottersWheel on 2018-06-29 21:50:11.
SUBMITTER: Graham Ladds
PROVIDER: MODEL1901300002 | biostudies-other |
SECONDARY ACCESSION(S): 30955892
REPOSITORIES: biostudies-other
Publications
Engineering a Model Cell for Rational Tuning of GPCR Signaling.
Cell 20190404 3
G protein-coupled receptor (GPCR) signaling is the primary method eukaryotes use to respond to specific cues in their environment. However, the relationship between stimulus and response for each GPCR is difficult to predict due to diversity in natural signal transduction architecture and expression. Using genome engineering in yeast, we constructed an insulated, modular GPCR signal transduction system to study how the response to stimuli can be predictably tuned using synthetic tools. We deline ...[more]
