Dataset Information
Simon2019 - NIK-dependent p100 processing into p52 and IkBd degradation, mass action, SBML 2v4
Ontology highlight
ABSTRACT: This model represents NIK-dependent p100 processing into p52 and NIK-dependent IkBd degradation with mass action kinetics. Compare this mass action representation to the Michaelis-Menten model. In this model the dose-response to increasing p100 mRNA is not monotonic due to substrate complex competition.
SUBMITTER: Lucian Smith
PROVIDER: MODEL1904020003 | biostudies-other |
SECONDARY ACCESSION(S): 10.1073/pnas.1816000116
REPOSITORIES: biostudies-other
Publications
Substrate complex competition is a regulatory motif that allows NFκB RelA to license but not amplify NFκB RelB.
Proceedings of the National Academy of Sciences of the United States of America 20190502 21
Signaling pathways often share molecular components, tying the activity of one pathway to the functioning of another. In the NFκB signaling system, distinct kinases mediate inflammatory and developmental signaling via RelA and RelB, respectively. Although the substrates of the developmental, so-called noncanonical, pathway are induced by inflammatory/canonical signaling, crosstalk is limited. Through dynamical systems modeling, we identified the underlying regulatory mechanism. We found that as ...[more]
