Dataset Information
Heiland2019 - NAD pathway model analysing the impact of NNMT on pathway dynamics and evolution
Ontology highlight
ABSTRACT:
SUBMITTER: Ines Heiland
PROVIDER: MODEL1905220001 | biostudies-other |
SECONDARY ACCESSION(S): 10.1073/pnas.1902346116
REPOSITORIES: biostudies-other
Publications
Subcellular compartmentation and differential catalytic properties of the three human nicotinamide mononucleotide adenylyltransferase isoforms.
The Journal of biological chemistry 20050823 43
Nicotinamide mononucleotide adenylyltransferase (NMNAT) is the central enzyme of the NAD biosynthetic pathway. Three human NMNAT isoforms have recently been identified, but isoform-specific functions are presently unknown, although a tissue-specific role has been suggested. Analyses of the subcellular localization confirmed NMNAT1 to be a nuclear protein, whereas NMNAT2 and -3 were localized to the Golgi complex and the mitochondria, respectively. This differential subcellular localization point ...[more]
