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Heiland2019 - Two compartment model of NAD biosynthesis and consumption

ABSTRACT: The model is based on MODEL1905220001 but has two compartments that have different composition of the biosynthetic enzymes NADA and NamPT. One compartment contains in addition NNMT, the other one does not. Both compartments are competing for a common Nam source.

SUBMITTER: Ines Heiland 

PROVIDER: MODEL1905220002 | biostudies-other |

SECONDARY ACCESSION(S): 10.1073/pnas.1902346116

REPOSITORIES: biostudies-other

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Publications

Subcellular compartmentation and differential catalytic properties of the three human nicotinamide mononucleotide adenylyltransferase isoforms.

Berger Felicitas F   Lau Corinna C   Dahlmann Mathias M   Ziegler Mathias M  

The Journal of biological chemistry 20050823 43

Nicotinamide mononucleotide adenylyltransferase (NMNAT) is the central enzyme of the NAD biosynthetic pathway. Three human NMNAT isoforms have recently been identified, but isoform-specific functions are presently unknown, although a tissue-specific role has been suggested. Analyses of the subcellular localization confirmed NMNAT1 to be a nuclear protein, whereas NMNAT2 and -3 were localized to the Golgi complex and the mitochondria, respectively. This differential subcellular localization point  ...[more]

PMID: 16118205

Publication: 1/10

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