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Seif2019 - Strain-specific metabolic models of Salmonella


ABSTRACT: Seif, 2019 - Systems biology and pangenome of Salmonella O-antigensStrain-specific metabolic models of Salmonella strains updated with O-antigen metabolic pathways.Locus-tags are updated in this version of the models to include both the prokka annotations and the refseq locus tags.

SUBMITTER: Yara Seif 

PROVIDER: MODEL1907100002 | biostudies-other |

SECONDARY ACCESSION(S): 31455646

REPOSITORIES: biostudies-other

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Publications

Systems Biology and Pangenome of <i>Salmonella</i> O-Antigens.

Seif Yara Y   Monk Jonathan M JM   Machado Henrique H   Kavvas Erol E   Palsson Bernhard O BO  

mBio 20190827 4


O-antigens are glycopolymers in lipopolysaccharides expressed on the cell surface of Gram-negative bacteria. Variability in the O-antigen structure constitutes the basis for the establishment of the serotyping schema. We pursued a two-pronged approach to define the basis for O-antigen structural diversity. First, we developed a bottom-up systems biology approach to O-antigen metabolism by building a reconstruction of <i>Salmonella</i> O-antigen biosynthesis and used it to (i) update 410 existing  ...[more]

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