Dataset Information
Rojano2019 - Blood Coagulation Model
Ontology highlight
ABSTRACT:
SUBMITTER: Matthew Roberts
PROVIDER: MODEL1907120001 | biostudies-other |
SECONDARY ACCESSION(S): 30900051
REPOSITORIES: biostudies-other
Publications
Kinetics of the coagulation cascade including the contact activation system: sensitivity analysis and model reduction.
Biomechanics and modeling in mechanobiology 20190321 4
Thrombus formation is one of the main issues in the development of blood-contacting medical devices. This article focuses on the modeling of one aspect of thrombosis, the coagulation cascade, which is initiated by the contact activation at the device surface and forms thrombin. Models exist representing the coagulation cascade by a series of reactions, usually solved in quiescent plasma. However, large parameter uncertainty involved in the kinetic models can affect the predictive capabilities of ...[more]