Dataset Information
DoldánMartelli2013 - A Mathematical Model for the Rational Design of Chimeric Ligands in Selective Drug Therapies
Ontology highlight
ABSTRACT: This model attempts to provide a mathematical framework for describing the dynamics of receptor-drug complex formation of chimeric drugs.
SUBMITTER: Tung Nguyen
PROVIDER: MODEL1907310001 | biostudies-other |
SECONDARY ACCESSION(S): 23887616
REPOSITORIES: biostudies-other
Publications
A mathematical model for the rational design of chimeric ligands in selective drug therapies.
CPT: pharmacometrics & systems pharmacology 20130213
Chimeric drugs with selective potential toward specific cell types constitute one of the most promising forefronts of modern Pharmacology. We present a mathematical model to test and optimize these synthetic constructs, as an alternative to conventional empirical design. We take as a case study a chimeric construct composed of epidermal growth factor (EGF) linked to different mutants of interferon (IFN). Our model quantitatively reproduces all the experimental results, illustrating how chimeras ...[more]
