Dataset Information
Bajzer2008 - Modeling of cancer virotherapy with recombinant measles viruses
Ontology highlight
ABSTRACT: This model describes the interactions between tumor cells and virus particles, with particular reference to virus-induced syncytium formation and ultimately death of tumor cells. Dynamics of infected cells, and production of new virus particules by infected cells, is also included.
SUBMITTER: Lucian Smith
PROVIDER: MODEL1907310005 | biostudies-other |
SECONDARY ACCESSION(S): 18316099
REPOSITORIES: biostudies-other
Publications
Modeling of cancer virotherapy with recombinant measles viruses.
Journal of theoretical biology 20080201 1
The Edmonston vaccine strain of measles virus has potent and selective activity against a wide range of tumors. Tumor cells infected by this virus or genetically modified strains express viral proteins that allow them to fuse with neighboring cells to form syncytia that ultimately die. Moreover, infected cells may produce new virus particles that proceed to infect additional tumor cells. We present a model of tumor and virus interactions based on established biology and with proper accounting of ...[more]
