Dataset Information
Wang2019 - A mathematical model of oncolytic virotherapy with time delay
Ontology highlight
ABSTRACT: A mathematical model describing oncolytic virotherapy with incorporation the viral lytic cycle and the virus-specific CTL response. The thresholds for viral treatment and virus-specific CTl response are also obtained.
SUBMITTER: Lucian Smith
PROVIDER: MODEL1908010001 | biostudies-other |
SECONDARY ACCESSION(S): 31137188
REPOSITORIES: biostudies-other
Publications
A mathematical model of oncolytic virotherapy with time delay.
Mathematical biosciences and engineering : MBE 20190301 4
Oncolytic virotherapy is an emerging treatment modality which uses replication-competent viruses to destroy cancers without causing harm to normal tissues. By the development of molecular biotechnology, many effective viruses are adapted or engineered to make them cancer-specific, such as measles, adenovirus, herpes simplex virus and M1 virus. A successful design of virus needs a full understanding about how viral and host parameters influence the tumor load. In this paper, we propose a mathemat ...[more]