Unknown

Dataset Information

0

Dong2014 - Mathematical modeling on helper t cells in a tumor immune system

ABSTRACT: 

This model gives a mathematical description of the interactions between tumor cells, cytotoxic T lymphocytes and helper T cells (HTCs) within the tumor microenvironment, with emphasis on the role played by HTCs. The effects and dynamics of adoptive cell immunotherapy and HTC recruitment are also specifically discussed.

SUBMITTER: Lucian Smith 

PROVIDER: MODEL1908080001 | biostudies-other |

SECONDARY ACCESSION(S): 10.3934/dcdsb.2014.19.55

REPOSITORIES: biostudies-other

Json Xml
altmetric image

Publications

Nonlinear dynamics of immunogenic tumors: parameter estimation and global bifurcation analysis.

Kuznetsov V A VA   Makalkin I A IA   Taylor M A MA   Perelson A S AS  

Bulletin of mathematical biology 19940301 2

We present a mathematical model of the cytotoxic T lymphocyte response to the growth of an immunogenic tumor. The model exhibits a number of phenomena that are seen in vivo, including immunostimulation of tumor growth, "sneaking through" of the tumor, and formation of a tumor "dormant state". The model is used to describe the kinetics of growth and regression of the B-lymphoma BCL1 in the spleen of mice. By comparing the model with experimental data, numerical estimates of parameters describing  ...[more]