Dataset Information
Lipniacki2004 - Mathematical model of NFKB regulatory module
Ontology highlight
ABSTRACT: its a mathematical model studying impact of TNF on NFKB nuclear dynamics. This model is derived from Hoffmann2002 (PMID:12424381).
SUBMITTER: Lucian Smith
PROVIDER: MODEL1908090003 | biostudies-other |
SECONDARY ACCESSION(S): 15094015
REPOSITORIES: biostudies-other
Publications
Mathematical model of NF-kappaB regulatory module.
Journal of theoretical biology 20040501 2
The two-feedback-loop regulatory module of nuclear factor kappaB (NF-kappaB) signaling pathway is modeled by means of ordinary differential equations. The constructed model involves two-compartment kinetics of the activators IkappaB (IKK) and NF-kappaB, the inhibitors A20 and IkappaBalpha, and their complexes. In resting cells, the unphosphorylated IkappaBalpha binds to NF-kappaB and sequesters it in an inactive form in the cytoplasm. In response to extracellular signals such as tumor necrosis f ...[more]
