Dataset Information
Alvarez2019 - A nonlinear mathematical model of cell-mediated immune response for tumor phenotypic heterogeneity
Ontology highlight
ABSTRACT: This is a non-linear mathematical model of cancer immunosurveillance that takes into account intratumoral phenotypic heterogeneity, such as differential expression of cell surface receptors and growth factors, according to cell-mediated immune responses. The model describes phenomena that have also been observed in vivo, such as tumor dormancy, cancer immunoediting, and a strong sensitivity to initial conditions.
SUBMITTER: Lucian Smith
PROVIDER: MODEL1908120003 | biostudies-other |
SECONDARY ACCESSION(S): 30930063
REPOSITORIES: biostudies-other
Publications
A nonlinear mathematical model of cell-mediated immune response for tumor phenotypic heterogeneity.
Journal of theoretical biology 20190329
Human cancers display intra-tumor heterogeneity in many phenotypic features, such as expression of cell surface receptors, growth, and angiogenic, proliferative, and immunogenic factors, which represent obstacles to a successful immune response. In this paper, we propose a nonlinear mathematical model of cancer immunosurveillance that takes into account some of these features based on cell-mediated immune responses. The model describes phenomena that are seen in vivo, such as tumor dormancy, rob ...[more]
