Dataset Information
ODea2007 - A homeostatic model of IκB metabolism to control constitutive NF-κB activity
Ontology highlight
ABSTRACT: Insert Citation Questions concerning the paper should be addressed to the corresponding author. Alexander Hoffmann (ahoffmann@ucsd.edu) The original model was written and simulated within MathWorks MatLab 2006a using the ode15s (stiff/NDF) solver. It is highly recommended that those wanting to model this system use the MatLab version which we will freely provide upon request. As always, simulation results vary according to the numerical solver used. Translation to SBML Level 2.1 was performed via reconstruction of the model within MathWorks SimBiology Desktop (version 2.1) followed by an Export to SBML.
SUBMITTER: Johannes Meyer
PROVIDER: MODEL1908270002 | biostudies-other |
SECONDARY ACCESSION(S): 17486138
REPOSITORIES: biostudies-other
Publications
A homeostatic model of IkappaB metabolism to control constitutive NF-kappaB activity.
Molecular systems biology 20070508
Cellular signal transduction pathways are usually studied following administration of an external stimulus. However, disease-associated aberrant activity of the pathway is often due to misregulation of the equilibrium state. The transcription factor NF-kappaB is typically described as being held inactive in the cytoplasm by binding its inhibitor, IkappaB, until an external stimulus triggers IkappaB degradation through an IkappaB kinase-dependent degradation pathway. Combining genetic, biochemica ...[more]
