Dataset Information
Ribba2018 - Mathematical Model of Tumor Uptake for Immunocytokine-Based Cancer Immunotherapy
Ontology highlight
ABSTRACT: This is a model developed to predict concentrations of cergutuzumab amunaleukin (CEA-IL2v) after various systemic dosing intensities.
SUBMITTER: Johannes Meyer
PROVIDER: MODEL1909050002 | biostudies-other |
SECONDARY ACCESSION(S): 29463551
REPOSITORIES: biostudies-other
Publications
Prediction of the Optimal Dosing Regimen Using a Mathematical Model of Tumor Uptake for Immunocytokine-Based Cancer Immunotherapy.
Clinical cancer research : an official journal of the American Association for Cancer Research 20180220 14
<b>Purpose:</b> Optimal dosing is critical for immunocytokine-based cancer immunotherapy to maximize efficacy and minimize toxicity. Cergutuzumab amunaleukin (CEA-IL2v) is a novel CEA-targeted immunocytokine. We set out to develop a mathematical model to predict intratumoral CEA-IL2v concentrations following various systemic dosing intensities.<b>Experimental Design:</b> Sequential measurements of CEA-IL2v plasma concentrations in 74 patients with solid tumors were applied in a series of differe ...[more]
