Dataset Information
Shariatpanahi2018 - Mathematical modeling of tumor-induced immunosuppression by myeloid-derived suppressor cells
Ontology highlight
ABSTRACT: This is a ODE-based mathematical model featuring equations describing the dynamics of tumor cells, cytotoxic T cells, natural killer cells, and myeloid-derived suppressor cells (MDSCs) that together describe the tumor-induced immunosuppression caused by MDSCs.
SUBMITTER: Johannes Meyer
PROVIDER: MODEL1909090003 | biostudies-other |
SECONDARY ACCESSION(S): 29337259
REPOSITORIES: biostudies-other
Publications
Mathematical modeling of tumor-induced immunosuppression by myeloid-derived suppressor cells: Implications for therapeutic targeting strategies.
Journal of theoretical biology 20180111
Myeloid-derived suppressor cells (MDSCs) belong to immature myeloid cells that are generated and accumulated during the tumor development. MDSCs strongly suppress the anti-tumor immunity and provide conditions for tumor progression and metastasis. In this study, we present a mathematical model based on ordinary differential equations (ODE) to describe tumor-induced immunosuppression caused by MDSCs. The model consists of four equations and incorporates tumor cells, cytotoxic T cells (CTLs), natu ...[more]
