Dataset Information
Varusai2018 - Dynamic modelling of the mTOR signalling network reveals complex emergent behaviours conferred by DEPTOR
Ontology highlight
ABSTRACT: This is a mathematical describing the effect that DEP domain-containing mTOR-interacting protein (DEPTOR) has on the mammalian target of rapamycin (mTOR) signalling network.
ORGANISM(S): Homo sapiens
SUBMITTER: Lucian Smith
PROVIDER: MODEL1909250003 | biostudies-other |
SECONDARY ACCESSION(S): 29330362
REPOSITORIES: biostudies-other
Publications
Dynamic modelling of the mTOR signalling network reveals complex emergent behaviours conferred by DEPTOR.
Scientific reports 20180112 1
The mechanistic Target of Rapamycin (mTOR) signalling network is an evolutionarily conserved network that controls key cellular processes, including cell growth and metabolism. Consisting of the major kinase complexes mTOR Complex 1 and 2 (mTORC1/2), the mTOR network harbours complex interactions and feedback loops. The DEP domain-containing mTOR-interacting protein (DEPTOR) was recently identified as an endogenous inhibitor of both mTORC1 and 2 through direct interactions, and is in turn degrad ...[more]
