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Puniya2021 - CD4+ Th1 cell metabolic model

ABSTRACT: CD4+ T cells are critical components in the human immune system. They produce cytokines to fight against pathogens and abnormal cells and stimulate other cells, such as B cells, macrophages, and neutrophils, to generate an immune response. T helper 1 (Th1) cells are subtypes of CD4+ T cells that differentiate from naive CD4+ T cells in a specific cytokine environment. The Th1 cell model consists of 3956 reactions, 2517 metabolites, and 1133 genes. CD4+ T cell models helped identify drug targets and repurposable drugs against autoimmune diseases.

SUBMITTER: Bhanwar Lal Puniya 

PROVIDER: MODEL1909260004 | biostudies-other |

SECONDARY ACCESSION(S): 10.1038/s41540-020-00165-3

REPOSITORIES: biostudies-other

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ATP-dependent transport of a novel thromboxane A2 receptor antagonist, [2-(4-chlorophenylsulfonylaminomethyl)indan-5-yl]acetate (Z-335) and its xenobiotic taurine conjugate (Z-335-Tau) by rat bile canalicular membrane vesicles.

Kawabata Yoshihiro Y   Kamada Emiko E   Furuta Shigeru S   Takei Mineo M   Kurimoto Tadashi T   Okudaira Kazuho K   Nishigaki Ryuichiro R  

Pharmaceutical research 20040301 3

<h4>Purpose</h4>The characteristics of bile canalicular transport processes for xenobiotic taurine conjugates have not yet been clarified. To elucidate the biliary excretion characteristics of xenobiotic taurine conjugates, we investigated the transport of a novel thromboxane A2 receptor antagonist, Z-335, and its taurine conjugate (Z-335-Tau) across the bile canalicular membrane.<h4>Methods</h4>We examined the uptake of Z-335 and Z-335-Tau by isolated bile canalicular membrane vesicles (CMVs) f  ...[more]

PMID: 15070098

Publication: 1/480

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