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Puniya2021 - CD4+ Th17 cell metabolism model

ABSTRACT: CD4+ T cells are critical components in the human immune system. They produce cytokines to fight against pathogens and abnormal cells and stimulate other cells, such as B cells, macrophages, and neutrophils, to generate an immune response. T helper 17 (Th17) cells are subtype CD4+ T cells that differentiate from naive CD4+ T cells in a specific cytokine environment. The Th17 cell model consists of 5282 reactions, 3263 metabolites, and 1250 genes. CD4+ T cell models helped identify drug targets and repurposable drugs against autoimmune diseases.

ORGANISM(S): Homo sapiens

SUBMITTER: Tung Nguyen 

PROVIDER: MODEL1909260006 | biostudies-other |

SECONDARY ACCESSION(S): 33483502

REPOSITORIES: biostudies-other

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Publications

ATP-dependent transport of a novel thromboxane A2 receptor antagonist, [2-(4-chlorophenylsulfonylaminomethyl)indan-5-yl]acetate (Z-335) and its xenobiotic taurine conjugate (Z-335-Tau) by rat bile canalicular membrane vesicles.

Kawabata Yoshihiro Y   Kamada Emiko E   Furuta Shigeru S   Takei Mineo M   Kurimoto Tadashi T   Okudaira Kazuho K   Nishigaki Ryuichiro R  

Pharmaceutical research 20040301 3

<h4>Purpose</h4>The characteristics of bile canalicular transport processes for xenobiotic taurine conjugates have not yet been clarified. To elucidate the biliary excretion characteristics of xenobiotic taurine conjugates, we investigated the transport of a novel thromboxane A2 receptor antagonist, Z-335, and its taurine conjugate (Z-335-Tau) across the bile canalicular membrane.<h4>Methods</h4>We examined the uptake of Z-335 and Z-335-Tau by isolated bile canalicular membrane vesicles (CMVs) f  ...[more]

PMID: 15070098

Publication: 1/596

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