Dataset Information
Boer1985 - Macrophage T cell interaction in anti-tumor response
Ontology highlight
ABSTRACT: In this paper we present a model of the macrophageT lymphocyte interactions that generate ananti-tumor immune response. The modseple cifies i)induction of cytotoxic T lymphocytes, ii) antigenpresentation by macrophages, which leads to iii)activation of helper T cells, and iv) production oflymphoid factors, which induce a) cytotoxic macrophages,b) T lymphocyte proliferation, and c) aninflammation reaction. Tumor escape mechanisms(suppression, antigenic heterogeneity) have beendeliberately omitted from the model.
SUBMITTER: Krishna Kumar Tiwari
PROVIDER: MODEL1911130003 | biostudies-other |
SECONDARY ACCESSION(S): 3156189
REPOSITORIES: biostudies-other
Publications
Macrophage T lymphocyte interactions in the anti-tumor immune response: a mathematical model.
Journal of immunology (Baltimore, Md. : 1950) 19850401 4
In this paper we present a model of the macrophage T lymphocyte interactions that generate an anti-tumor immune response. The model specifies i) induction of cytotoxic T lymphocytes, ii) antigen presentation by macrophages, which leads to iii) activation of helper T cells, and iv) production of lymphoid factors, which induce a) cytotoxic macrophages, b) T lymphocyte proliferation, and c) an inflammation reaction. Tumor escape mechanisms (suppression, antigenic heterogeneity) have been deliberate ...[more]
