Dataset Information
Tiwari2019 - Mathematical model of NFKB regulatory module with TNF and ROS
Ontology highlight
ABSTRACT: It is a dynamic model containing elements of two different model as one. It contains the impact of TNF on SOD and impact of ROS on A20 behavior.
ORGANISM(S): Mus musculus
SUBMITTER: Krishna Kumar Tiwari
PROVIDER: MODEL1911140002 | biostudies-other |
SECONDARY ACCESSION(S): 32573648
REPOSITORIES: biostudies-other
Publications
Mathematical model of NF-kappaB regulatory module.
Journal of theoretical biology 20040501 2
The two-feedback-loop regulatory module of nuclear factor kappaB (NF-kappaB) signaling pathway is modeled by means of ordinary differential equations. The constructed model involves two-compartment kinetics of the activators IkappaB (IKK) and NF-kappaB, the inhibitors A20 and IkappaBalpha, and their complexes. In resting cells, the unphosphorylated IkappaBalpha binds to NF-kappaB and sequesters it in an inactive form in the cytoplasm. In response to extracellular signals such as tumor necrosis f ...[more]
