Dataset Information
Nikolaev2019 - Immunobiochemical reconstruction of influenza lung infection-melanoma skin cancer interactions
Ontology highlight
ABSTRACT: This is a mathematical mechanistic immunobiochemical model that incorporates T cell pathways that control programmed cell death protein 1 (PD-1) expression. A core component of the model is a kinetic motif, termed a PD-1 Double Incoherent Feed-Forward Loop (DIFFL), which reflects known interactions between IRF4, Blimp-1, and Bcl-6.
ORGANISM(S): Mus musculus
SUBMITTER: Lucian Smith
PROVIDER: MODEL1911180001 | biostudies-other |
SECONDARY ACCESSION(S): 30745900
REPOSITORIES: biostudies-other
Publications
Immunobiochemical Reconstruction of Influenza Lung Infection-Melanoma Skin Cancer Interactions.
Frontiers in immunology 20190128
It was recently reported that acute influenza infection of the lung promoted distal melanoma growth in the dermis of mice. Melanoma-specific CD8+ T cells were shunted to the lung in the presence of the infection, where they expressed high levels of inflammation-induced cell-activation blocker PD-1, and became incapable of migrating back to the tumor site. At the same time, co-infection virus-specific CD8+ T cells remained functional while the infection was cleared. It was also unexpectedly found ...[more]
