Dataset Information
Yu2019 - A mathematical model of tumor-immune interactions with an immune checkpoint inhibitor
Ontology highlight
ABSTRACT: This is a mathematical model investigating interactions among malignant tumor cells, CD4+ T cells, anti-tumor cytokines (specifically IFN-gamma), and the immune checkpoint inhibitor CTLA-4 to assess the importance of immune checkpoints in mediating tumor regression.
ORGANISM(S): Mus musculus
SUBMITTER: Johannes Meyer
PROVIDER: MODEL1911270002 | biostudies-other |
SECONDARY ACCESSION(S): 10.1016/j.amc.2019.06.037
REPOSITORIES: biostudies-other
Publications
Modeling anti-tumor Th1 and Th2 immunity in the rejection of melanoma.
Journal of theoretical biology 20100505 3
Recent experiments indicate that CD4(+) Th2 cells can reject skin tumors in mice, while CD4(+) Th1 cells cannot (Mattes et al., 2003; Zhang et al., 2009). These results are surprising because CD4(+) Th1 cells are typically considered to be capable of tumor rejection. We used mathematical models to investigate this unexpected outcome. We found that neither CD4(+) Th1 nor CD4(+) Th2 cells could eliminate the cancer cells when acting alone, but that tumor elimination could be induced by recruitment ...[more]