Dataset Information
Lim2014 - HTLV-I infection A dynamic struggle between viral persistence and host immunity
Ontology highlight
ABSTRACT: This is a four-dimensional, non-linear system of ordinary differential equations that describes the dynamic interactions among viral expression, infected target cell activation, and the HTLV-I-specific CTL response.
ORGANISM(S): Homo sapiens
SUBMITTER: Lucian Smith
PROVIDER: MODEL1912100003 | biostudies-other |
SECONDARY ACCESSION(S): 24583256
REPOSITORIES: biostudies-other
Publications
Modelling the role of Tax expression in HTLV-I persistence in vivo.
Bulletin of mathematical biology 20110421 12
Human T-lymphotropic virus type I (HTLV-I) is a persistent human retrovirus characterized by life-long infection and risk of developing HAM/TSP, a progressive neurological and inflammatory disease, and adult T-cell leukemia (ATL). Chronically infected individuals often harbor high proviral loads despite maintaining a persistently activated immune response. Based on a new hypothesis for the persistence of HTLV-I infection, a three-dimensional compartmental model is constructed that describes the ...[more]
