Dataset Information
Caravagna2010 - Tumour suppression by immune system
Ontology highlight
ABSTRACT: Tumour suppression by immune system through stochastic oscillationsGiulioCaravagnaa Albertod’Onofriob PaoloMilazzoaRobertoBarbutiahttps://doi.org/10.1016/j.jtbi.2010.05.013AbstractThe well-known Kirschner–Panetta model for tumour–immune System interplay [Kirschner, D., Panetta, J.C., 1998. Modelling immunotherapy of the tumour–immune interaction. J. Math. Biol. 37 (3), 235–252] reproduces a number of features of this essential interaction, but it excludes the possibility of tumour suppression by the immune system in the absence of therapy. Here we present a hybrid–stochastic version of that model. In this new framework, we show that in reality the model is also able to reproduce the suppression, through stochastic extinction after the first spike of an oscillation.
ORGANISM(S): Homo sapiens
SUBMITTER: Lucian Smith
PROVIDER: MODEL2001200001 | biostudies-other |
SECONDARY ACCESSION(S): 20580640
REPOSITORIES: biostudies-other
Publications
Tumour suppression by immune system through stochastic oscillations.
Journal of theoretical biology 20100516 3
The well-known Kirschner-Panetta model for tumour-immune System interplay [Kirschner, D., Panetta, J.C., 1998. Modelling immunotherapy of the tumour-immune interaction. J. Math. Biol. 37 (3), 235-252] reproduces a number of features of this essential interaction, but it excludes the possibility of tumour suppression by the immune system in the absence of therapy. Here we present a hybrid-stochastic version of that model. In this new framework, we show that in reality the model is also able to re ...[more]
