Unknown

Dataset Information

0

Floc'hlay2020 - SeaUrchin_model_ginsim

ABSTRACT: Multilevel logical model encompassing the Nodal and BMP pathways together with key transcription factors setting the dorsal-ventral axis in the sea urchin P. lividus embryo. This model accounts for the specification of wild-type ventral ectoderm, ciliary band and dorsal ectoderm, and further recapitulates sophisticated mutant phenotypes.

SUBMITTER: Denis Thieffry 

PROVIDER: MODEL2002190001 | biostudies-other |

SECONDARY ACCESSION(S): 33298464

REPOSITORIES: biostudies-other

Json Xml
altmetric image

Publications

Deciphering and modelling the TGF-β signalling interplays specifying the dorsal-ventral axis of the sea urchin embryo.

Floc'hlay Swann S   Molina Maria Dolores MD   Hernandez Céline C   Haillot Emmanuel E   Thomas-Chollier Morgane M   Lepage Thierry T   Thieffry Denis D  

Development (Cambridge, England) 20210120 2

During sea urchin development, secretion of Nodal and BMP2/4 ligands and their antagonists Lefty and Chordin from a ventral organiser region specifies the ventral and dorsal territories. This process relies on a complex interplay between the Nodal and BMP pathways through numerous regulatory circuits. To decipher the interplay between these pathways, we used a combination of treatments with recombinant Nodal and BMP2/4 proteins and a computational modelling approach. We assembled a logical model  ...[more]

Similar Datasets

Unknown The 39 item Parkinson's disease questionnaire (PDQ-39) revisited: implications for evidence based medicine.
| S-EPMC2117601 | biostudies-literature
Unknown Cultural adaptation and psychometric evaluation of the Kinyarwanda version of the diabetes-39 (D-39) questionnaire.
| S-EPMC9382791 | biostudies-literature
Genomics Brain_22A-Scrapie_End-point_PR04-39-to-46_using_GPL7118
2008-09-30 | GSE12321 | GEO
Unknown Breast regression protein-39 (BRP-39) promotes dendritic cell maturation in vitro and enhances Th2 inflammation in murine model of asthma.
| S-EPMC4001840 | biostudies-literature
Unknown Gender dysphoria in a 39-year-old man.
| S-EPMC3883823 | biostudies-literature
Unknown Landscape of Microsatellite Instability Across 39 Cancer Types.
| S-EPMC5972025 | biostudies-literature
Unknown Inhomogeneous terminators on the exoplanet WASP-39 b.
| S-EPMC11357994 | biostudies-literature
Unknown Target gene analyses of 39 amelogenesis imperfecta kindreds.
| S-EPMC3292789 | biostudies-literature
Transcriptomics Transcriptomic Profiling of 39 Neuroblastoma Cell Lines
2017-02-07 | GSE89413 | GEO
Genomics CGH analysis of 39 Lactococcus lactis strains.
2008-12-31 | GSE12638 | GEO