Dataset Information
Wu2017 - Murine Bevacizumab PK model
Ontology highlight
ABSTRACT:
SUBMITTER: Krishna Kumar Tiwari
PROVIDER: MODEL2003030003 | biostudies-other |
SECONDARY ACCESSION(S): 22391791
REPOSITORIES: biostudies-other
Publications
Pharmacokinetics, lymph node uptake, and mechanistic PK model of near-infrared dye-labeled bevacizumab after IV and SC administration in mice.
The AAPS journal 20120306 2
Our objective was to determine the pharmacokinetics, bioavailability and lymph node uptake of the monoclonal antibody bevacizumab, labeled with the near-infrared (IR) dye 800CW, after intravenous (IV) and subcutaneous (SC) administration in mice. Fluorescence imaging and enzyme-linked immunosorbent assay (ELISA) assays were developed and validated to measure the concentration of bevacizumab in plasma. The bevacizumab-IRDye conjugate remained predominantly intact in plasma and in lymph node homog ...[more]
