Dataset Information
Grigolon2018 - Responses to auxin signals
Ontology highlight
ABSTRACT: Plants depend on the signalling of the phytohormone auxin for their development and for responding to environmental perturbations. The associated biomolecular signalling network involves a negative feedback on Aux/IAA proteins which mediate the influence of auxin (the signal) on the auxin response factor (ARF) transcription factors (the drivers of the response). To probe the role of this feedback, we consider alternative in silico signalling networks implementing different operating principles. By a comparative analysis, we find that the presence of a negative feedback allows the system to have a far larger sensitivity in its dynamical response to auxin and that this sensitivity does not prevent the system from being highly resilient. Given this insight, we build a new biomolecular signalling model for quantitatively describing such Aux/IAA and ARF responses.
ORGANISM(S): unidentified plant
SUBMITTER: Ahmad Zyoud
PROVIDER: MODEL2003060002 | biostudies-other |
SECONDARY ACCESSION(S): 29410878
REPOSITORIES: biostudies-other
Publications
Responses to auxin signals: an operating principle for dynamical sensitivity yet high resilience.
Royal Society open science 20180124 1
Plants depend on the signalling of the phytohormone auxin for their development and for responding to environmental perturbations. The associated biomolecular signalling network involves a negative feedback on Aux/IAA proteins which mediate the influence of auxin (the <i>signal</i>) on the auxin response factor (ARF) transcription factors (the <i>drivers</i> of the response). To probe the role of this feedback, we consider alternative <i>in silico</i> signalling networks implementing different o ...[more]
