Dataset Information
Tang2019 - Pharmacology modelling of AURKB and ZAK interaction in TNBC
Ontology highlight
ABSTRACT: Aurora Kinase B and ZAK interaction model
Equivalent of the stochastic model used in "Network pharmacology model predicts combined Aurora B and ZAK inhibition in MDA-MB-231 breast cancer cells" by Tang et. al. 2018.The only difference is cell division and partitioning of the components, which are available in the original model for SGNS2.
ORGANISM(S): Homo sapiens
SUBMITTER: Lucian Smith
PROVIDER: MODEL2004230001 | biostudies-other |
SECONDARY ACCESSION(S): 31312514
REPOSITORIES: biostudies-other
Publications
Network pharmacology modeling identifies synergistic Aurora B and ZAK interaction in triple-negative breast cancer.
NPJ systems biology and applications 20190708
Cancer cells with heterogeneous mutation landscapes and extensive functional redundancy easily develop resistance to monotherapies by emerging activation of compensating or bypassing pathways. To achieve more effective and sustained clinical responses, synergistic interactions of multiple druggable targets that inhibit redundant cancer survival pathways are often required. Here, we report a systematic polypharmacology strategy to predict, test, and understand the selective drug combinations for ...[more]
