Dataset Information
Goldbeter2013-Oscillatory activity of cyclin-dependent kinases in the cell cycle
Ontology highlight
ABSTRACT: A model for oscillations of Cdc2 kinase in embryonic cell cycles based on Michaelis–Menten phosphorylation–dephosphorylation kinetics shows that the occurrence and amplitude of the oscillations strongly depend on the ultrasensitivity of the enzymatic cascade that controls the activity of the cyclin-dependent kinase.
SUBMITTER: Lucian Smith
PROVIDER: MODEL2005050002 | biostudies-other |
SECONDARY ACCESSION(S): 23892075
REPOSITORIES: biostudies-other
Publications
A minimal cascade model for the mitotic oscillator involving cyclin and cdc2 kinase.
Proceedings of the National Academy of Sciences of the United States of America 19911001 20
A minimal model for the mitotic oscillator is presented. The model, built on recent experimental advances, is based on the cascade of post-translational modification that modulates the activity of cdc2 kinase during the cell cycle. The model pertains to the situation encountered in early amphibian embryos, where the accumulation of cyclin suffices to trigger the onset of mitosis. In the first cycle of the bicyclic cascade model, cyclin promotes the activation of cdc2 kinase through reversible de ...[more]
