Dataset Information
Hardiansyah2019 - QSP model of chimeric antigen receptor T-Cell therapy
Ontology highlight
ABSTRACT: This QSP model explains how the mechanism of action connects to the clinical outcomes and, therefore, may serve as an important model-based platform to guide the development and personalized dosing of the CART therapy.
ORGANISM(S): Homo sapiens
SUBMITTER: Krishna Kumar Tiwari
PROVIDER: MODEL2009230001 | biostudies-other |
SECONDARY ACCESSION(S): 30990958
REPOSITORIES: biostudies-other
Publications
Quantitative Systems Pharmacology Model of Chimeric Antigen Receptor T-Cell Therapy.
Clinical and translational science 20190420 4
Chimeric antigen receptor T-cell (CART) therapy is a new and promising cancer therapy. However, severe toxicity due to cytokine release syndrome (CRS) in CART-treated patients highlighted the possible danger of this new therapy. Disease burden and CART doses are the potential factors associated with CRS but the detail relationships between these factors and the severity of the CRS remain largely unknown. In this study, the quantitative systems pharmacology (QSP) approach is used to quantify the ...[more]