Dataset Information
Kurlovics2021 - Metformin partitioning between plasma and RBC with independent Kin and Kout coefficients
Ontology highlight
ABSTRACT: This model is a supplementary material of a manuscript"Diffusion driven metformin exchange transport rates between plasma and red blood cells"by Janis Kurlovics, Darta Maija Zake, Linda Zaharenko, Kristaps Berzins, Janis Klovins, Egils StalidzansThe setting of the model correspond to Fig.2 for the case with a single coefficient for experimental values of average concentration curve. Parameter estimation can be executed using experimental data file "average_exp_data.txt".A=B if metformin concentration is 0 at t=0.
ORGANISM(S): Homo sapiens
SUBMITTER: Lucian Smith
PROVIDER: MODEL2103170002 | biostudies-other |
SECONDARY ACCESSION(S): 10.1007/s40262-021-01058-2
REPOSITORIES: biostudies-other
Publications
Metformin Transport Rates Between Plasma and Red Blood Cells in Humans.
Clinical pharmacokinetics 20210726 1
<h4>Background</h4>Metformin has been used for the treatment of type 2 diabetes for over 60 years; however, its mechanism of pharmacological action is not fully clear. Different hypotheses exist regarding metformin distribution and redistribution mechanisms between plasma and erythrocytes/red blood cells (RBCs).<h4>Objective</h4>We aimed to test the hypothesis that the metformin distribution between plasma and RBC occurs via concentration difference-driven passive transport and estimated transpo ...[more]
