Dataset Information
Ciliberto2005 - Steady states and oscillations in the p53/Mdm2 network
Ontology highlight
ABSTRACT: Its a mathematial model studying steady state and oscialltions in p53-MDM2 network triggered by IR induced DNA Damage.
ORGANISM(S): Homo sapiens
SUBMITTER: Lucian Smith
PROVIDER: MODEL2104140001 | biostudies-other |
SECONDARY ACCESSION(S): 15725723
REPOSITORIES: biostudies-other
Publications
Steady states and oscillations in the p53/Mdm2 network.
Cell cycle (Georgetown, Tex.) 20050318 3
p53 is activated in response to events compromising the genetic integrity of a cell. Recent data show that p53 activity does not increase steadily with genetic damage but rather fluctuates in an oscillatory fashion. Theoretical studies suggest that oscillations can arise from a combination of positive and negative feedbacks or from a long negative feedback loop alone. Both negative and positive feedbacks are present in the p53/Mdm2 network, but it is not known what roles they play in the oscilla ...[more]
