Dataset Information
Zhang2007 - Mechanism of DNA damage response (Model2)
Ontology highlight
ABSTRACT: Its a mechanistic model explaining the impact of p53 on apoptosis decision. This model represents schema 2 of manuscript.
ORGANISM(S): Homo sapiens
SUBMITTER: Tung Nguyen
PROVIDER: MODEL2106230001 | biostudies-other |
SECONDARY ACCESSION(S): 17245126
REPOSITORIES: biostudies-other
Publications
Exploring mechanisms of the DNA-damage response: p53 pulses and their possible relevance to apoptosis.
Cell cycle (Georgetown, Tex.) 20070112 1
The transcription factor p53 plays a central role in maintaining genomic integrity. Recent experiments in MCF7 cells have shown that p53 protein level rises and falls in distinct pulses in response to DNA damage. The amplitudes of and intervals between pulses seem to be independent of the extent of damage, and some cells generate regular pulses of p53 over many days. Identifying the molecular mechanisms responsible for such interesting behavior is an important and challenging problem. This paper ...[more]
