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Lopacinski2021 - Coxsackievirus B3 (CVB3) complete kinetics ODE model

ABSTRACT: Encoded model contains complete kinetics of infection for coxsackievirus B3 (CVB3), a compact and fast-acting RNA virus. The model consists of separable, detailed modules describing viral binding-delivery, translation-replication, and encapsidation. Specific module activities are dampened by the type I interferon response to viral double-stranded RNAs (dsRNAs), which is itself disrupted by viral proteinases

SUBMITTER: Kevin Janes 

PROVIDER: MODEL2110250001 | biostudies-other |

SECONDARY ACCESSION(S): 33740397

REPOSITORIES: biostudies-other

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Modeling the complete kinetics of coxsackievirus B3 reveals human determinants of host-cell feedback.

Lopacinski Aaron B AB   Sweatt Andrew J AJ   Smolko Christian M CM   Gray-Gaillard Elise E   Borgman Cheryl A CA   Shah Millie M   Janes Kevin A KA  

Cell systems 20210318 4

Complete kinetic models are pervasive in chemistry but lacking in biological systems. We encoded the complete kinetics of infection for coxsackievirus B3 (CVB3), a compact and fast-acting RNA virus. The model consists of separable, detailed modules describing viral binding-delivery, translation-replication, and encapsidation. Specific module activities are dampened by the type I interferon response to viral double-stranded RNAs (dsRNAs), which is itself disrupted by viral proteinases. The experi  ...[more]

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