Dataset Information
Leander2021 - innate immune response to SARS-CoV-2 in the alveolar epithelium
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Krishna Kumar Tiwari
PROVIDER: MODEL2111170001 | biostudies-other |
SECONDARY ACCESSION(S): 34430043
REPOSITORIES: biostudies-other
Publications
A model of the innate immune response to SARS-CoV-2 in the alveolar epithelium.
Royal Society open science 20210811 8
We present a differential equation model of the innate immune response to SARS-CoV-2 within the alveolar epithelium. Critical determinants of the viral dynamics and host response, including type I and type II alveolar epithelial cells, interferons, chemokines, toxins and innate immune cells, are included. We estimate model parameters, compute the within-host basic reproductive number, and study the impacts of therapies, prophylactics, and host/pathogen variability on the course of the infection. ...[more]
