Dataset Information
Lopez2022 - Genome-scale metabolic network of Haemophilus influenzae RdKW20 (iNL638)
Ontology highlight
ABSTRACT:
ORGANISM(S): Haemophilus influenzae 22.1-21
SUBMITTER: Tung Nguyen
PROVIDER: MODEL2204040002 | biostudies-other |
SECONDARY ACCESSION(S): 35293791
REPOSITORIES: biostudies-other
Publications
Interrogation of Essentiality in the Reconstructed Haemophilus influenzae Metabolic Network Identifies Lipid Metabolism Antimicrobial Targets: Preclinical Evaluation of a FabH β-Ketoacyl-ACP Synthase Inhibitor.
mSystems 20220316 2
Expediting drug discovery to fight antibacterial resistance requires holistic approaches at system levels. In this study, we focused on the human-adapted pathogen Haemophilus influenzae, and by constructing a high-quality genome-scale metabolic model, we rationally identified new metabolic drug targets in this organism. Contextualization of available gene essentiality data within <i>in silico</i> predictions identified most genes involved in lipid metabolism as promising targets. We focused on t ...[more]