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Pearce2021 - Fibrin Polymerization

ABSTRACT: Here is an ode model for in vitro fibrin matrix polymerization reproducing interactions among fibrinogen, fibrin and other proteins involved in the homeostatic phase of wound healing.

ORGANISM(S): Homo sapiens

SUBMITTER: Lucian Smith

PROVIDER: MODEL2204200001 | biostudies-other |

SECONDARY ACCESSION(S): 33751272

REPOSITORIES: biostudies-other

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Publications

Modeling and Parameter Subset Selection for Fibrin Polymerization Kinetics with Applications to Wound Healing.

Pearce Katherine J KJ Nellenbach Kimberly K Smith Ralph C RC Brown Ashley C AC Haider Mansoor A MA

Bulletin of mathematical biology 20210322 5

During the hemostatic phase of wound healing, vascular injury leads to endothelial cell damage, initiation of a coagulation cascade involving platelets, and formation of a fibrin-rich clot. As this cascade culminates, activation of the protease thrombin occurs and soluble fibrinogen is converted into an insoluble polymerized fibrin network. Fibrin polymerization is critical for bleeding cessation and subsequent stages of wound healing. We develop a cooperative enzyme kinetics model for in vitro ...[more]

PMID: 33751272

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