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Lu2019 - Genome scale metabolic model for Saccharomyces cerevisiae - yeastGEM8.5.0

ABSTRACT: yeast-GEM: The consensus genome-scale metabolic model of Saccharomyces cerevisiae. Further curations of this model will be tracked in the GitHub repository:https://github.com/SysBioChalmers/yeast-GEM For you use yeast-GEM, please cite the yeast8 paper: Lu, H. et al. A consensus S. cerevisiae metabolic model Yeast8 and its ecosystem for comprehensively probing cellular metabolism. Nature Communications 10, 3586 (2019). https://doi.org/10.1038/s41467-019-11581-3. The FROG analysis was performed with the yeastGEM_rich_medium.mat, which is a rich medium setup.

ORGANISM(S): C14271

SUBMITTER: Tung Nguyen 

PROVIDER: MODEL2204280003 | biostudies-other |

SECONDARY ACCESSION(S): 31395883

REPOSITORIES: biostudies-other

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Publications

Nucleocytosolic acetyl-coenzyme a synthetase is required for histone acetylation and global transcription.

Takahashi Hidekazu H   McCaffery J Michael JM   Irizarry Rafael A RA   Boeke Jef D JD  

Molecular cell 20060701 2

Metabolic enzymes rarely regulate informational processes like gene expression. Yeast acetyl-CoA synthetases (Acs1p and 2p) are exceptional, as they are important not only for carbon metabolism but also are shown here to supply the acetyl-CoA for histone acetylation by histone acetyltransferases (HATs). acs2-Ts mutants exhibit global histone deacetylation, transcriptional defects, and synthetic growth defects with HAT mutants at high temperatures. In glycerol with ethanol, Acs1p is an alternate  ...[more]

PMID: 16857587

Publication: 1/379

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