Nikolov2020 - p53-miR34 model

ABSTRACT: Svetoslav Nikolov, Olaf Wolkenhauer, Julio Vera & Momchil Nenov. The role of cooperativity in a p53-miR34 dynamical mathematical model. Journal of Theoretical Biology 495 (2020).

The objective of this study is to evaluate the role of cooperativity, captured by the Hill coefficient, in a minimal mathematical model describing the interactions between p53 and miR-34a. The model equations are analyzed for negative, none and normal cooperativity using a specific version of bifurcation theory and they are solved numerically. Special attention is paid to the sign of so-called first Lyapunov value. Interpretations of the results are given, both according to dynamic theory and in biological terms. In terms of cell signaling, we propose the hypothesis that when the outgoing signal of a

ORGANISM(S): Homo sapiens

SUBMITTER: Lucian Smith 

PROVIDER: MODEL2205180001 | biostudies-other |

SECONDARY ACCESSION(S): 10.1016/j.jtbi.2020.110252

REPOSITORIES: biostudies-other