Dataset Information
Amstein2022 - TNFR1 Signal Transduction, Petri Net
Ontology highlight
ABSTRACT:
SUBMITTER: Ann-Kathrin Otto
PROVIDER: MODEL2210170001 | biostudies-other |
SECONDARY ACCESSION(S): 35994517
REPOSITORIES: biostudies-other
Publications
LUBAC-Recruited CYLD and A20 Regulate Gene Activation and Cell Death by Exerting Opposing Effects on Linear Ubiquitin in Signaling Complexes.
Cell reports 20151206 10
Ubiquitination and deubiquitination are crucial for assembly and disassembly of signaling complexes. LUBAC-generated linear (M1) ubiquitin is important for signaling via various immune receptors. We show here that the deubiquitinases CYLD and A20, but not OTULIN, are recruited to the TNFR1- and NOD2-associated signaling complexes (TNF-RSC and NOD2-SC), at which they cooperate to limit gene activation. Whereas CYLD recruitment depends on its interaction with LUBAC, but not on LUBAC's M1-chain-for ...[more]
