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Immunological Model of sphingolipids with IL-6/IL-17/IL-23 in L. major infection

ABSTRACT: In diseased state, we demonstrated that increase in production of sphingosine-1-phosphate and overexpression of IL-6,lL-17 and IL-23 with SATB1 leads to disease progression.

SUBMITTER: Shailza Singh 

PROVIDER: MODEL2301110001 | biostudies-other |

SECONDARY ACCESSION(S): 36494028

REPOSITORIES: biostudies-other

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Decoding systems immunological model of sphingolipids with IL-6/IL-17/IL-23 axes in L. major infection.

Jawale Diksha D   Khandibharad Shweta S   Singh Shailza S  

Biochimica et biophysica acta. Molecular and cell biology of lipids 20221207 2

IL-6, IL-17, IL-23 and IL-1β are the crucial cytokines controlling inflammatory and immune response during L. major infection. During cutaneous leishmaniasis, an important T helper cell type CD4<sup>+</sup> Th17 subset plays a deterministic role in lesion formation through channelling infected macrophages and production of IL-1β, IL-6, IL-23 and IFN-γ. Ceramide derived sphingosine precursors may assist in pro-inflammatory cytokine response. However, the role of these metabolites in inflammation  ...[more]

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