Dataset Information
Harish2009 - nuclear–cytoplasmic ERK oscillation model
Ontology highlight
ABSTRACT:
SUBMITTER: Yirui Chen
PROVIDER: MODEL2306170002 | biostudies-other |
SECONDARY ACCESSION(S): 19953086
REPOSITORIES: biostudies-other
Publications
Rapid and sustained nuclear-cytoplasmic ERK oscillations induced by epidermal growth factor.
Molecular systems biology 20091201
Although the ERK pathway has a central role in the response of cells to growth factors, its regulatory structure and dynamics are incompletely understood. To investigate ERK activation in real time, we expressed an ERK-GFP fusion protein in human mammary epithelial cells. On EGF stimulation, we observed sustained oscillations of the ERK-GFP fusion protein between the nucleus and cytoplasm with a periodicity of approximately 15 min. The oscillations were persistent (>45 cycles), independent of ce ...[more]
