Dataset Information
Zerrouk2023 - Large scale computational modeling of the M2 synovial macrophage in rheumatoid arthritis
Ontology highlight
ABSTRACT:
SUBMITTER: naouel zerrouk
PROVIDER: MODEL2307180002 | biostudies-other |
SECONDARY ACCESSION(S): 38272919
REPOSITORIES: biostudies-other
Publications
Macrophage Polarization: Different Gene Signatures in M1(LPS+) vs. Classically and M2(LPS-) vs. Alternatively Activated Macrophages.
Frontiers in immunology 20190524
Macrophages are found in tissues, body cavities, and mucosal surfaces. Most tissue macrophages are seeded in the early embryo before definitive hematopoiesis is established. Others are derived from blood monocytes. The macrophage lineage diversification and plasticity are key aspects of their functionality. Macrophages can also be generated from monocytes <i>in vitro</i> and undergo classical (LPS+IFN-γ) or alternative (IL-4) activation. <i>In vivo</i>, macrophages with different polarization an ...[more]
