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Gulhane2022 - Sphingolipid metabolism and PI3K-AKT axis in NSCLC

ABSTRACT: In this model, we demonstrated that the increased expression of sphingolipids enzyme affects PI3K-AKT signaling axis and its downstream signaling mediators resulting in cancer progression

SUBMITTER: Shailza Singh 

PROVIDER: MODEL2402290001 | biostudies-other |

SECONDARY ACCESSION(S): 35977046

REPOSITORIES: biostudies-other

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MicroRNA-520c-3p impacts sphingolipid metabolism mediating PI3K/AKT signaling in NSCLC: Systems perspective.

Gulhane Pooja P   Singh Shailza S  

Journal of cellular biochemistry 20220817 11

Increasing research suggests that sphingolipid metabolism is essential for the progression and metastasis of cancer. The underlying mechanistic insight into the dysregulation of sphingolipid metabolism affecting pathways is poorly investigated. As a result, the goal of the current study was to glean knowledge from the systems biology approach to investigate how the sphingolipid metabolism affects the signal transduction network in non-small cell lung cancer (NSCLC), the most common type of cance  ...[more]

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