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SanchezVillanueva2024 - APL resistance model

ABSTRACT: This logical network model integrate signalling, transcriptional and epigenetic regulatory mechanisms underlying the the Acute Promyelocytic Leukaemia cell responses to RA treatment depending on their genetic background. The explicit inclusion of the histone methyltransferase EZH2 allowed us to assess its role in the maintenance of the resistant phenotype, distinguishing between its canonical and non-canonical activities. Ultimately, this model offers a solid basis to assess the roles of novel regulatory mechanisms, as well as to explore novel therapeutical approaches in silico.

SUBMITTER: Denis Thieffry 

PROVIDER: MODEL2403140001 | biostudies-other |

SECONDARY ACCESSION(S): 10.1093/bib/bbaf002

REPOSITORIES: biostudies-other

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Publications

C/EBPbeta: a major PML-RARA-responsive gene in retinoic acid-induced differentiation of APL cells.

Duprez Estelle E   Wagner Katharina K   Koch Heike H   Tenen Daniel G DG  

The EMBO journal 20031101 21

In acute promyelocytic leukemia (APL), the translocation t(15;17) induces a block at the promyelocytic stage of differentiation in an all-trans-retinoic acid (ATRA)-responsive manner. Here we report that upon treatment with ATRA, t(15;17) cells (NB4) reveal a very rapid increase in protein level and binding activity of C/EBPbeta, a C/EBP family member, which was not observed in an ATRA-resistant NB4 cell line. We further provide evidence that ATRA mediates a direct increase of C/EBPbeta, only in  ...[more]

PMID: 14592978

Publication: 1/66

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