Dataset Information
Mechanotransduction & Inflammation
Ontology highlight
ABSTRACT: Deep review of our previous model MODEL2302150001 and publication Dent et al., 2015 (Mechanotransduction map: simulation model, molecular pathway, gene set) with more mechanical stimuli and specific attention to the impact on inflammation and on the AhR receptor.
SUBMITTER: Christine Nardini
PROVIDER: MODEL2406110001 | biostudies-other |
SECONDARY ACCESSION(S): 10.1016/j.mbm.2024.100112
REPOSITORIES: biostudies-other
Publications
Wnt/β-catenin signaling pathway in uterine leiomyoma: role in tumor biology and targeting opportunities.
Molecular and cellular biochemistry 20210517 9
Uterine leiomyoma is the most common tumor of the female reproductive system and originates from a single transformed myometrial smooth muscle cell. Despite the immense medical, psychosocial, and financial impact, the exact underlying mechanisms of leiomyoma pathobiology are poorly understood. Alterations of signaling pathways are thought to be instrumental in leiomyoma biology. Wnt/β-catenin pathway appears to be involved in several aspects of the genesis of leiomyomas. For example, Wnt5b is ov ...[more]
